Mitochondrial
Aging
Protecting
against mitochondrial aging
Massive free radical damage occurs in the cells' energy power plants
(the mitochondria), which can overwhelm the cells' antioxidant defense
systems. Mitochondrial damage due to aging is a serious health problem
in elderly people, whose energy levels decline precipitously even
when they remain disease-free.
N-acetyl-cysteine (NAC) has been shown to stimulate glutathione production
for the purpose of providing protection against free radicals that
are continuously being generated in mitochondria. In addition to protecting
against mitochondrial free radical damage, NAC has been shown to reduce
the effect of intracellular hydrogen peroxide by 93%.(123) Supplemental
NAC can reduce the frequency and duration of infectious diseases.
NAC is used as a mucous dissolving agent in chronic bronchitis,(125-128)
an antidote for liver damage induced by acetaminophen (the pain reliever),
and an inhibitor of hemorrhagic inflammation of the urinary bladder
caused by tumor suppressing drugs.
Free
radical damage is both a causative and contributing factor in the
development of degenerative disease. Scientists are now concentrating
on specific free radicals, the different part of the cell that these
free radicals attack, and the types of antioxidants that are needed
to provide intra- and inter-cellular protection against oxidative
stress. Life Extension Mix provides antioxidants, such as 600 mg of
NAC and 500 mg of taurine per daily dose, to protect against differing
types of free radicals both inside and outside of cells.
Facilitating
youthful methylation
Enzymatic and genetic activity throughout the body depends on the
continuous re-methylation of DNA. The age-related breakdown of youthful
methylation metabolism predisposes the body to a wide range of degenerative
diseases. Maintaining healthy methylation patterns protects against
DNA mutations that damage cells and can cause cancer.
Vitamin
B12 works synergistically with folic acid and TMG to enhance DNA methylation
and reduce toxic homocysteine in the blood. Scientific studies confirm
that orally administered vitamin B-12 supplements are effectively
absorbed by more than 99% of humans without gastric related diseases.
Vitamin
B12 plays a critical role in many enzymatic processes required to
maintain good health. Elderly people can suffer from severe neurological
impairment if they are deficient in vitamin B12. Life Extension Mix
contains high doses of folic acid and three different types of vitamin
B12 along with a small amount of trimethylglycine..
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