References:

1. Hoppe, H.A. (1975) Drogenkunde Band 1 Angiospermien, 8th ed., DeGryter, Berlin, New York.

2. Teuscher E. (1989) Pharmakognosie - Biogene Arzneimittel, 3th ed.,Akademie Verlag Berlin.

3. Achterrath-Tuckermann, U.; Kunde, R.; Flaskamp, E.; Isaac, O.; Thiemer, K. (1980) Planta Med. 39, 38-50.

4. Kraft, K. (1997) Phytomedicine 4(4), 369-378.

5. Bashir, A.K.; Abdalla, A.A.; Wasfi, I.A.; Hassan, E.S.; Amiri, M.H.; Crabb, T.A. (1994) Int. J. Pharmacog. 32(4), 366-372.

6. Shin, K.H.; Kang, S.S.; Kim, H.J.; Shin, S.W. (1994) Phytomedicine 1(2), 145-147.

7. Glinkowska, G.; Strzelecka H. (1987) Acta Pol. Pharm. XLIV(5), 476.

8. Czeczot, H.; Tudek, B.; Kuszelak, T.; Szymczyk, T.; Dobrowolska, B.; Glinkowska, G. (1990) Mutation Res. 240, 209-216.

9. Nagao, M.; Morita, N.; Yahagi, T.; Shimizu, M.; Kuroyanagi, M.; Fukuoka, M. (1981) Environ. Mutagen. 3(4), 401-419.

10. Sanchez de Rojas, V.R.; Somoza, B.; Ortega, T.; Villar, A.M. (1996) Planta Med. 62(3), 272-274.

11. Son, K.H.; Park, J.O.; Chung, K.C.; Chang, H.W.; Kim J.S. (1992) Arch. Pharm. Res. 15, 365-370.

12. Yanoshita, R.; Chang, H.W.; Son, K.H.; Kudo, I.; Samejima Y. (1996) Inflamm. Res. 45, 546-549.

13. Perez-Garcia, F., Adzet, T., Canigueral, S., Free Radic. Res., (2000), 33(5), 661-665.

14. Rice-Evans, C.A.; Miller, N.J.; Paganga, G. (1997) Trends in Plant Science 2, 152-159.

15. Miller, N.J. (1996) „Natural Antioxidants and Food Quality in Atherosclerosis and Cancer Prevention", Kumpulainen, J.T.; Salonen, J.T. eds; The Royal Society of Chemistry, 256-259.

16. Igile, G.O.; Oleszek, W.; Jurzysta, M.; Burda, S.; Fafunso, M.; Fasanmade, A.A. (1994) J. Agric. Food Chem. 42(11), 2445-2448.

17. Cotelle, N.; Bernier, J.L.; Catteau, J.P.; Pommery, J.; Wallet, J.C.;Gaydou, E.M. (1996) Free Radic. Biol. Med. 20(1), 35-43.

18. Tournaire, C.; Croux, S.; Maurette, M.-T.; Beck, I.; Hocquaux, M.; Braun, A.M.; Oliveros, E. (1993) J. Photochem. Photobiol. B: Biol. 19, 205-215.

19. Cos, P.; Calomme, M.; Hu, J.P.; Cimanga, K.V.; .Poel, B.; Pieters, L.; Vlietinck, A.J. (1998) J. Nat. Prod. 61, 71-76.

20. Cai, Q.; Rahn, R.O.; Zhang, R. (1997) Cancer Lett. 119, 99-107.

21. Kong, L. D., Wolfender, J. L., Cheng, C. H., Hostettmann, K., Tan, R. X., Planta Med., (1999), 65(8), 744-746.

22. Yokozawa, T.; Dong, E.; Liu, Z.W.; Shimizu, M. (1997) Phytother. Res. 11, 446-449.

23.Galvez, J.; Dela Cruz, J.P.; Zarzuelo, A.; De la Cuesta, F.S. (1995) Pharmacology 51(2), 127-133.

24.Cholbi, M.R.; Paya, M.; Alcaraz, M.J. (1991) Experientia 47(2), 195-199.

25. Gebhardt, R. (1995) 43rd Annual Congress, Soc. Med. Plant. Res., Halle, Germany.

26. Schussler, M., Holzl, J., Fricke, U. (1995). Arzneimittelforschung, 45( 8), 842-845.

27. Occhiuto, F.; Busa, G.; Ragusa, S.; De Pasquale, A. (1991) Phytother. Res. 5, 9-14.

28.Du, S. H., Jin, J. S., Chin. Herb. Med. J., (1996), 27, 416-417.

29. Wang, L. Y., Han, C. H., Wang, P., Li, G. Y., Xu, S. Y. (1986) Chin. Pharmacol. Bull, 2, 34-36.

30. Lin, C.N.; Kuo, S.H.; Chung M.I. (1997) J. Nat. Prod. 60, 851-853.

31. Duarte, J. Perez, Vizcaino F., Utrilla, P., Jimenez, J., Tamargo, J., Zarzuelo, A., Gen Pharmacol., (1993), 24(4), 857-862.

32. Chan, E. C., Pannangpetch, P., Woodman, O. L., Cardiovasc. Pharmacol., (2000), 35(2), 326-333.

33. Chang, W.C., Hsu, F. L., Prostaglandins Leukot Essent Fatty Acids, (1992), 45(4), 307-312.

34. Kaneko, T., Baba, N., Biosci Biotechnol. Biochem., (1999), 63(2), 323-328.

35. Post, J.F.M.; Varma, R.S. (1992) Cancer Lett. 67(2-3), 207-213.

36. Ramanthan, R.; Das, N.P.; Tan, C.H. (1993) Int. J. Oncol. 3, 115-119.

37. Elangovan, V.; Ramamoorthy, N.; Balasubramanian, S.; Sekar, N.; Govindasamy, S. (1994) Indian J Pharmacol. 26(4), 266-269.

38. Ryu, S.Y.; Choi, S.U.; Lee, C.O.; Lee, S.H.; Ahn, J.W.; Zee, O.P. (1994) Arch.Pharm. Res. 17(1), 42-44.

39. Fotsis, T.; Pepper, M.S.; Aktas, E.; Breit, S.; Rasku, S.; Adlercreutz, H.; Wähälä, K.; Montesano, R.; Schweigerer, L. (1997) Cancer Res. 57(14), 2916-2921.

40.Ubeda, A.; Esteve, M.L.; Alcaraz, M.J.; Cheeseman, K.H.; Slater, T.F. (1995) Phytother. Res. 9(6), 416-420.

41. Elangovan, V.; Ramamoorthy, N.; Balasubramanian, S.; Sekar, N.; Govindasamy, S. (1994) Indian J Pharmacol. 26(4), 266-269.

42. Edenharder, R.; Rauscher, R.; Platt, K.L. (1997) Mutation Res. 379, 21-32.

43. Taj, S.; Nagarajan, B. (1996) Mutation Res. 369(1,2), 97-106.

44. Elangovan, V.; Sekar, N.; Govindasamy, S. (1995) Cancer Lett. 87, 107-113.

45. Colerangle, J.B.; Roy, D. (1995) Int. J. Oncol. 7, 1361-1366.

46. Chen, C.W.; Palangat, M.; Oberley, T.D.; Roy, D. (1996) Int. J. Oncol. 9(4), 811-814.

47. Liu, Y. C., Hung, C. F., Yeh, F. T., Food Chem Toxicol., (2001), 39(7), 641-647.

48. Samejima, K., Kanazawa, K., Ashida, H., Danno, G., J. Agric. Fodd Chem., (1995), 43(2), 410-414.

49. Tachibans, K.; Okada, Y.; Okuyama, T. (1995) Nat. Med. 49(3), 266-268.

50. Yamamoto H., Food style, 1998, 21(2), 71-74.
Yamamoto H, Sakakibara J, Nagatsu A, Sekiya, J. Agric. Food Chem., 1998, 46, 3, 862-865.

51. Chen M, Jin W, Dai L, Xu S ,Zhongguo Yaolixue Yu Dulixue Zazhi, 1986, 1(1), 46-52.

52. Yamamoto H., Food style, 1998, 21(2), 71-74.
Yamamoto H, Sakakibara J, Nagatsu A, Sekiya, J. Agric. Food Chem., 1998, 46, 3, 862-865.

53. Tordera M, Ferrandiz ML, Alcaraz, Z Naturforsch [C]., 1994, 30; 49(3-4):235-40.

54. Merfort, I.; Heilmann, J.; Hagedorn-Leweke, U.; Lippold, B. C. (1994). Pharmazie 49(7), 509-11.

55. Jin, W. Z., Dai, L. M., Li, Y. F., Chen, M. Z., Acta Anhui Med Univ, (1985), 20, 14-15.

56. Kim, H. K., Cheon, B. S., Kim, S. Y., Kim, H. P., Biochem. Pharmacol., (1999), 58, 759-765.

57. Kim, J. S.; Kwon, C. S., and Son, K. H., Biosci Biotechnol Biochem., 2000, 64(11):2458-61.

58. Cheong H, Ryu S-Y, Oak M-H, Cheon S-H, Yoo G-S, Kim K-M, Arch Pharmacol Res, 1998, 21, 4, 478-480.

59. Rainova L, Gakhniyan R, Farmatsiya (Sofia), 1978, 28(5), 39-42.

60. Varma, S.D.; Mikumi, I.; Kinoshita, J.H. (1975) Science 186, 1215-1221.

61. Matsuda, H.; Cai, H.; Kubo, M.; Tosa, H.; Linuma, M. (1995) Bio. Pharm. Bull. 18(3), 463-466.

62. Kimata M, Shichijo M, Miura T, Serizawa I, Inagaki N, Nagai H, Clin Exp Allergy, 2000, 30(4):501-8

63. Kimata M, Inagaki N, Nagai H, Planta Med., 2000, 66, 1, 25-29.

64. Yamada K, Matsuo N, Shoji K et al., ACS Symp Ser, 1998, 701, 198-208.

65. Amellal M, Bronner C, Briancon F et al., Planta Med, 1985, 1, 16-20.

66. Shen C-H., Yao Hsueh T’ung Pao, 1980, 15, 12, 36.

67. Hiremath, S. P., Badami, S., Hunasagatta,S. K., Patil, S. B.(2000) Eur. J. Pharmacol 391(1-2), 193-197.

68. Wleklik, M.; Luczak, M.; Panasiak, W.; Kobus, M.; Lammer-Zarawska, E. (1988) Acta Virol. 32(6), 522-525.

69. Vrijsen, R.; Everaet, L.; Boeye, A. (1988) J. Gen. Virol. 69(7), 1749-1751.

70. Kusumoto, I.T.; Hattori, M.; Miyaichi, Y.; Tomimori, T.; Hanaoka, M.; Namba, T. (1991) Shoyakugaku Zasshi 45(3), 240-254.

72. Tsou, M. F., Chen, G. W., Hung, C. F., Microbios, (2001), 104, 408, 87-97.

73. Simoes, C. M., Schenkel, E. P., Bauer, L., Langeloh, A., J. Ethnopharmacology, (1988), 22(3),, 281-293.

74. Chung, J. G., hsia, T. C., kuo, H. M., Toxicol in vitro, (2001), 15(3), 191-198.

75. Ciaceri, G., Attaguile, G., Minerva Med., (1972), 63(29), 1665-1668.

76. Saller, R.; Reichling, J.; Hellenbrecht, D. (1995) Phytotherapie - klinische, pharmakologische und pharmazeutische Grundlagen, K.F. Haug Verlag,Heidelberg.

77. Shimoi, K.; Masuda, S.; Furugori, M.; Esaki, S.; Kinae, N. (1994) Carcinogenesis 15(11), 2669-2672.

78. Horiuchi, T., Fujiki, H., Hakii, H., Suganuma, M., Yamashita, K. Sugimura, T., Jpn J. Cancer Res., (1986), 77(6), 526-531.

79. Kuppusamy, U.R; Das, N.P. (1991) Experientia 47(11-12), 1196-1200.

80. Zhou, Z. D., Wang, L. Y., Wang, P. (1979) Chin. Herb Med. Commun. 10, 35.

81. Annui Cooperation Group, Preliminary experimental study of Aruga decumbens Thunb. against chronic bronchitis, (1973) Chin. Herb. Med. Commun. 2, 18-23.

82. Amellal, M.; Bronner, C.; Briancon, F.; Haag, M.; Anton, R.; Landry, Y. (1994) Planta Med. 1, 16-20.

83. Kawasaki, M.; Toyda, M.; Teshima, R.; Sawada, J.; Hayashi, T.; Arisawa, M.;Shimzu, M. (1994)
Shokuhin Eiseigaku Zasshi (J. Food Hyg. Soc. Japan) 35(5), 497-503.

84. Mittra, B., Saha, A., Chowdhury, A. R., Pal, C., Mandal, S., Mukhopadhyay, S., Bandyopadhyay, S., Majumder, H. K., Mol. Med., 6(6), 527-541.

85. Block, L. C.; Santos, A. R.; de Souza, M. M.; Scheidt, C.; Yunes, R. A.; Santos, M. A.; Monache, F. D.;
Filho, V. (1998). J Ethnopharmacol. 61(1), 85-9.

88. Pieroni, A.; Pachaly, P.; Huang, Y.; Van Poel, B., and Vlietinck, A. J., J Ethnopharmacol., 2000, 70(3):213-7.

89. Rump, A. F.; Schussler, M.; Acar, D.; Cordes, A.; Theisohn, M.; Rosen, R.; Klaus, W., and Fricke, U, Gen Pharmacol., 25(6):1137-42.

90. Park, K. Y.; Lee, S. H.; Min, B. K.; Lee, K. S.; Choi, J. S.; Chung, S. R.; Min, K. R., and Kim, Y, Planta Med., 1999, 65(5):457-9.

91. Zarzuelo A, Jimenez I, Gamez MJ, Utrilla P, et al., Life Sciences, 1996, 58, 25, 2311-2316.

92. Shimoi, K.; Saka, N.; Kaji, K.; Nozawa, R., and Kinae, N., Biofactors, 2000, 12(1-4):181-6.

93. Chen, M. Z., Feng, R. J., Gu, Y. Z., Guang, L. X., Zhen, Y. W., Wang, G. B., Li, W. P., Xu, S. Y. (1986) Chin. Pharmacol. Bull. 2, 15-20.

94. Wang (2000) Drugs of the future. 25(2), 146-149.

95. Spencer, J. P. E., Chowrimootoo, G., Choudhury, R, Debnam, E. S., Kaila Srai, S., Rice-Evans, C., FEBS Lett., (1999), 458, 224-230.

96. Peng, H.; Xiang, S.; Bi, Z. (1981) Yao Hsueh T´ung Pao 16(ISS 2), 11-13.

97. Chavant, L.; Combier, H.; Cros, J. (1975) Plant. Med. Phytother. 9(4), 267-272.

98. Dai, L. M., Cheng, H., Li, W. P., Liu, S. Q., Chen, M. Z., Xu, S. Y. (1985) Acta Anhui Med. Univ. 20, 1-3.

99. Fiszer-Szafaraz, B. (1984) Analyt. Biochem. 143, 76-84.

100. Formica, J.V.; Regelson, W. (1995) Food Chem. Toxicol. 33, 1061-1080.

101. MacGregor, J.T.; Jurd, L. (1978) Mutation Res. 54, 297-309

102. Gebhardt R. New experimental results in the action of artichoke leaf extract. Zeitschrift fur Allgemeinmed
1996;72:20–3.

103. Brown JE, Rice-Evans CA. Luteolin rich artichoke extract protects low density lipoprotein from oxidation in vitro. Free Radical Research 1998;29:247–55.

104. Yanoshita R, et al. Inhibition of lysoPAF acetyltransferase activity by flavonoids. Inflamm Res 1996 Nov;45(1:);546-9

105. Ma JY, et al. A sesquiterpene lactone glucoside from Ixeris denticulata f. pinnatipartita. Phytochemistry 1999 Jan;50(1):113-5

106. Matsukawa Y, et al. Genistein arrests cell cycle progression at G2-M. <span class="referenceItal">Cancer Res 1993 Mar 15;53(6):1328-31

107. Post JF, et al. Growth inhibitory effects of bioflavonoids and related compounds on human leukemic CEM-C1 and CEM-C7 cells. Cancer Lett 1992 Dec 24;67(2-3):207-13.

108. Makino T, et al. Inhibitory effect of Perilla frutescens and its phenolic constituents on cultured murine mesangial cell proliferation. Planta Med 1998 Aug;64(6):541-5.

109. Shimoi K, et al. Radioprotective effects of antioxidative plant flavonoids in mice. Mutat Res 1996 Feb 19;350(1):153-61.

110. Garcia-Closas R, et al. Intake of specific carotenoids and flavonoids and the risk of gastric cancer in Spain. Cancer Causes Control1999 Feb;10(1):71-5.

111. Walaszek Z, et al. D-glucaric acid content of various fruits and vegetables and cholesterol-lowering effects of dietary D-glucarate in the rat. Nutrition Research (United States) 1996, 16/4 (673-681).

112. Oredipe OA, et al. Dietary glucarate-mediated inhibition of initiation of diethylnitrosamine-induced hepatocarcinogenesis. Toxicology; 74 (2-3). 1992. 209-222.

113. Walaszek Z, et al. Dietary glucarate-mediated reduction of sensitivity of murine strains to chemical carcinogenesis. Cancer Lett 1986 Oct;33(1):25-32.

114. Hirano T, et al. Antiproliferative effects of synthetic and naturally occurring flavonoids on tumor cells of the human breast carcinoma cell line, ZR-75-1. Res Commun Chem Pathol Pharmacol 1989 Apr;64(1):69-78.

115. Kuiper GG, et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998 Oct;139(10):4252-63.

116. Noroozi M, et al. Effects of flavonoids and vitamin C on oxidative DNA damage to human lymphocytes. Am J Clin Nutr 1998 Jun;67(6):1210-8.

117. Wang IK, et al. Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur J Cancer 1999 Oct;35(10):1517-25.

118. Takahashi T, et al. Structure-activity relationships of flavonoids and the induction of granulocytic- or monocytic-differentiation in HL60 human myeloid leukemia cells. Biosci Biotechnol Biochem 1998 Nov;62(11):2199-204.

119. Boege F, et al. Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase. J Biol Chem 1996 Jan 26;271(4):2262-70.

120. Kawaii S, et al. Effect of citrus flavonoids on HL-60 cell differentiation. Anticancer Res 1999 Mar-Apr; 19(2A):1261-9.

121. Yin F, et al. Signal pathways involved in apigenin inhibition of growth and induction of apoptosis of human anaplastic thyroid cancer cells (ARO). Anticancer Res 1999 Sep-Oct;19(5B):4297-303.

122. Yin F, et al. Growth inhibitory effects of flavonoids in human thyroid cancer cell lines. Thyroid 1999 Apr;9(4):369-76.